Mini reviews in medicinal chemistry, 2002-12, Vol.2 (6), p.553-563
2002
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Polyamine metabolism as chemotherapeutic target in protozoan parasites
- Ist Teil von
- Mini reviews in medicinal chemistry, 2002-12, Vol.2 (6), p.553-563
- Ort / Verlag
- Netherlands
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1389-5575DOI: 10.2174/1389557023405549Titel-ID: cdi_pubmed_primary_12370040
- Format
- –
- Schlagworte
- Adenosylmethionine Decarboxylase - antagonists & inhibitors, Animals, Antiprotozoal Agents - pharmacology, Antiprotozoal Agents - therapeutic use, Drug Therapy, Combination, Eflornithine - pharmacology, Eflornithine - therapeutic use, Eukaryota - drug effects, Eukaryota - metabolism, Polyamines - metabolism, Protozoan Infections - drug therapy