Details

Autor(en) / Beteiligte

• Hone, David M
• DeVico, Anthony L
• Fouts, Timothy R
• Onyabe, David Y
• Agwale, Simon M
• Wambebe, Charles O
• Blattner, William A
• Gallo, Robert C
• Lewis, George K

Titel

Development of vaccination strategies that elicit broadly neutralizing antibodies against human immunodeficiency virus type 1 in both the mucosal and systemic immune compartments

Ist Teil von

• Journal of human virology, 2002-01, Vol.5 (1), p.17

Ort / Verlag

United States

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• The antigenic diversity, rapid genetic integration into host cell DNA, and immune evasion tactics of human immunodeficiency virus type 1 (HIV-1) create formidable obstacles to the development of an effective vaccine against it. In spite of this, the advent of conformationally constrained HIV-1 Env and gp120 immunogens has made it feasible to formulate HIV-1 vaccines that induce broadly cross-reactive neutralizing antibodies and afford protection through humoral mechanisms. This paper reviews recent advances made by the authors toward the development of an HIV-1 vaccine that elicits such antibodies in both the mucosal and systemic immune compartments.