Details

Autor(en) / Beteiligte

• Liu, Da-lie
• Li, Xi-jun
• Zhang, Yang
• Li, Yu-xia

Titel

Effect of exogenous hyaluronan on wound healing

Ist Teil von

• Zhongguo xiu fu chong jian wai ke za zhi, 2002-07, Vol.16 (4), p.256

Ort / Verlag

China

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the mechanism of impeded wound healing by exogenous hyaluronan (HA). Wound healing models were established on 18 adult rabbit ears, which were randomly divided into 3 groups, the 2% HA treated-group (group A), the 1% HA treated-group(group B), and the PBS control group (group C). The process of wound healing was observed morphologically and histologically. The expression of alpha-smooth muscle actin in fibroblast was measured by immunohistochemical method. 1. The mean values of wound healing time of groups A, B and C were (11.7 +/- 0.6), (11.3 +/- 0.6), and (10.8 +/- 1.0) days respectively. Wound contraction was greater in group C than in group A and group B. 2. Compared with PBS controls, the collagen fibril was slender and arrayed regularly in HA treated wound. 3. The expression of alpha-smooth muscle actin was greater in group C than in groups A and B. It is one of reasons of impeded wound healing that exogenous HA inhibits the expression of alpha-smooth muscle protein and wound contraction.