Details

Autor(en) / Beteiligte

• GAMMON, Marilie D
• WOLFF, Mary S
• HATCH, Maureen
• SENIE, Ruby
• BERKOWITZ, Gertrud
• BRADLOW, H. Leon
• GARBOWSKI, Gail
• MAFFEO, Carla
• MONTALVAN, Pat
• KEMENY, Margaret
• CITRON, Marc
• SCHNABEL, Freya
• NEUGUT, Alfred I
• SCHUSS, Allan
• HAJDU, Steven
• VINCEGUERRA, Vincent
• NIGUIDULA, Nancy
• IRELAND, Karen
• SANTELLA, Regina M
• ENG, Sybil M
• TEITELBAUM, Susan L
• BRITTON, Julie A
• TERRY, Mary Beth
• LEVIN, Bruce
• STELLMAN, Steven D
• KABAT, Geoffrey C

Titel

Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood

Ist Teil von

• Cancer epidemiology, biomarkers & prevention, 2002-08, Vol.11 (8), p.686-697

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2002

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Whether environmental contaminants increase breast cancerrisk among women on Long Island, NY, is unknown. The study objective is to determine whether breast cancer risk is increased in relation to organochlorines, compounds with known estrogenic characteristics that were extensively used on Long Island and other areas of the United States. Recent reports do not support a strong association, although there are concerns with high risks observed in subgroups of women. Blood samples from 646 case and 429 control women from a population-based case-control study conducted on Long Island were analyzed. No substantial elevation in breast cancer risk was observed in relation to the highest quintile of lipid-adjusted serum levels of p,p ′-bis(4-chlorophenyl)-1,1-dichloroethene (DDE) [odds ratio (OR), 1.20 versus lowest quintile; 95% confidence interval (CI), 0.76–1.90], chlordane (OR, 0.98; 95% CI, 0.62–1.55), dieldrin (OR, 1.37; 95% CI, 0.69–2.72), the sum of the four most frequently occurring PCB congeners (nos. 118, 153, 138, and 180; OR, 0.83; 95% CI, 0.54–1.29), and other PCB congener groupings. No dose-response relations were apparent. Nor was risk increased in relation to organochlorines among women who had not breastfed or were overweight, postmenopausal, or long-term residents of Long Island; or with whether the case was diagnosed with invasive rather than in situ disease, or with a hormone receptor-positive tumor. These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women.