Details

Autor(en) / Beteiligte

• Deaney, C L
• Feyi, K
• Forrest, C M
• Freeman, A
• Harman, G
• McDonald, M S
• Petrie, A
• Shaw, S J
• Stone, T W
• Stoy, N
• Darlington, L G

Titel

Levels of lipid peroxidation products in a chronic inflammatory disorder

Ist Teil von

• Research communications in molecular pathology and pharmacology, 2001-07, Vol.110 (1-2), p.87

Ort / Verlag

United States

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• We have examined the plasma levels of the lipid peroxidation products 4-hydroxy-nonenal and malondialdehyde in a carefully controlled study of age and sex-matched subjects with rheumatoid arthritis in whom potentially confounding influences such as disease modifying anti-rheumatic drugs (DMARDs), self-medication and vitamin supplements were eliminated. The plasma concentrations of the antioxidants uric acid and vitamin E were also measured. The results reveal a strong and consistent inverse correlation between the levels of lipid peroxidation products in the plasma and erythrocyte sedimentation rate (ESR). There is no indication that vitamin E or urate function as the major antioxidant agent in arthritis, as has been suggested in more seriously affected patients. It is concluded that there is no evidence that vitamin E is more important, and urate less important as an antioxidant in mild arthritis. The correlation between lipid peroxidation and ESR suggests a more complex relationship than has been assumed.