Details

Autor(en) / Beteiligte

• Porjesz, Bernice
• Almasy, Laura
• Edenberg, Howard J
• Wang, Kongming
• Chorlian, David B
• Foroud, Tatiana
• Goate, Alison
• Rice, John P
• O'Connor, Sean J
• Rohrbaugh, John
• Kuperman, Samuel
• Bauer, Lance O
• Crowe, Raymond R
• Schuckit, Marc A
• Hesselbrock, Victor
• Conneally, P Michael
• Tischfield, Jay A
• Li, Ting-Kai
• Reich, Theodore
• Begleiter, Henri

Titel

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3729-3733

Ort / Verlag

United States: National Acad Sciences

Erscheinungsjahr

2002

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13–28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABA A ) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA A receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.