Details

Autor(en) / Beteiligte

• Dima, V F
• Vasiliu, V
• Dima, S V

Titel

Photodynamic therapy: an update

Ist Teil von

• Romanian archives of microbiology and immunology, 1998-07, Vol.57 (3-4), p.207

Ort / Verlag

Romania

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• Photodynamic therapy (PDT) is a promising local treatment modality based on the selective accumulation of a photosensitizer in malignant tissues and the subsequent irradiation with laser light. Photodynamic therapy of malignant tumors includes biological, photochemical and photophysical processes. These processes involve: (a) absorption of photosensitizing agent; (b) selective retention of the photosensitizer in tumors and (c) irradiation of sensitized tumor by laser radiation. This report provides a review of photosensitizers, photochemistry, subcellular targets, side effects and laser involved in photodynamic therapy. In addition, gradual increase in knowledge related to in vitro and in vivo mechanisms of action of PDT, as well as some clinical applications of photodynamic therapy are presented.