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Hepatitis is a frequent complication of cytomegalovirus infection in the immunocompetent as well as the immunocompromised host. Current knowledge of liver involvement in different groups of subjects undergoing cytomegalovirus infection, such as congenitally infected newborns, immunocompetent adults, transplant recipients and AIDS patients, will be summarized in this chapter. Furthermore, a recently identified population at risk for cytomegalovirus infection, hepatopathic patients, will be described.