Details

Autor(en) / Beteiligte

• Levario-Carrillo, M
• Feria-Velasco, A
• De Celis, R
• Ramos-Martínez, E
• Córdova-Fierro, L
• Solís, F J

Titel

Parathion, a cholinesterase-inhibiting plaguicide induces changes in tertiary villi of placenta of women exposed: a scanning electron microscopy study

Ist Teil von

• Gynecologic and obstetric investigation, 2001-01, Vol.52 (4), p.269-275

Ort / Verlag

Switzerland

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of this work was to describe the anatomy of placentas from women who were at risk of exposure to parathion during their pregnancy, when examined with the light and scanning electron microscopes. Twenty term placentas were analyzed; 10 from women living in an agricultural area, who were at risk of exposure to parathion during their pregnancy, and 10 from women living in an urban area, not expressly exposed to pesticides. Each sample was examined with both light and scanning electron microscopes. Cholinesterase activity was significantly reduced in blood from women of the exposed group. In some placentas of women exposed to parathion, recent microinfarctions, microcalcifications and increased deposition of fibrinoid material were seen, along with a larger proportion of atypical characteristics of villi, such as bullous and balloon-like formations with nonhomogeneous surface, and other areas devoid of microvilli. These observations suggest that in chronic exposure to pesticides, the rate of atypical characteristics of placental villi increases, which could be related to changes in the fetus biology. In this study, one newborn from the exposed group showed intrauterine growth retardation and another one, some signs of hypoxia.