Anticancer research, 2001-07, Vol.21 (4A), p.2429
2001
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- Autor(en) / Beteiligte
- Titel
- Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma
- Ist Teil von
- Anticancer research, 2001-07, Vol.21 (4A), p.2429
- Ort / Verlag
- Greece
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Differential display (DD) analysis using surgically resected human hepatocellular carcinoma (HCC) and adjacent non-tumorous liver tissues was performed. We identified 5 cDNAs up-regulated in human hepatocellular carcinoma, encoding S8, L12, L23a, L27 and L30 ribosomal protein mRNAs. Northern blot analysis, using total RNAs from thirteen pairs of HCC and abjacent non-tumorous liver tissues demonstrated that these mRNA levels were up-regulated along with the histological grading of tumors. The expression of these mRNAs was also high in three human HCC cell lines (HuH-7, HepG2 and HLF), irrespective of the growth state. These results suggest that activation of these genes is an important manifestation of HCC phenotypes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0250-7005Titel-ID: cdi_pubmed_primary_11724303
- Format
- –
- Schlagworte
- Blotting, Northern, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - metabolism, DNA, Complementary - genetics, DNA, Complementary - isolation & purification, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Liver Neoplasms - genetics, Liver Neoplasms - metabolism, Ribosomal Proteins - biosynthesis, Ribosomal Proteins - genetics, RNA, Messenger - biosynthesis, RNA, Messenger - genetics, Tumor Cells, Cultured, Up-Regulation