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Biosynthesis of neurosteroids and regulation of their synthesis
Ist Teil von
International review of neurobiology, 2001, Vol.46, p.33-78
Ort / Verlag
United States
Erscheinungsjahr
2001
Quelle
MEDLINE
Beschreibungen/Notizen
The brain, like the gonads, adrenal glands, and placenta, is a steroidogenic organ. The steroids synthesized by the brain and by the nervous system, given the name neurosteroids, have a wide variety of diverse functions. In general, they mediate their actions not through classic steroid hormone nuclear receptors but through ion-gated neurotransmitter receptors. This chapter summarizes the biochemistry of the enzymes involved in the biosynthesis of neurosteroids, their localization during development and in adulthood, and the regulation of their expression, highlighting both similarities and differences between expression in the brain and in classic steroidogenic tissues.