Details

Autor(en) / Beteiligte

• DELGADO, Guillermo
• DEL SOCORRO OLIVARES, María
• CHáVEZ, María Isabel
• RAMíREZ-APAN, Teresa
• LINARES, Edelmira
• BYE, Robert
• ESPINOSA-GARCíA, Francisco J.

Titel

Antiinflammatory Constituents from Heterotheca inuloides

Ist Teil von

• Journal of natural products (Washington, D.C.), 2001-07, Vol.64 (7), p.861-864

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• Three new compounds, cadalen-15-oic acid (1), 3,7-dihydroxy-3(4H)-isocadalen-4-one (2), and dicadalenol (3), were isolated from the aerial parts of Heterotheca inuloides (Mexican arnica), together with the known compounds 7-hydroxycadalene (4), 7-hydroxy-4alphaH-3,4-dihydrocadalene (5), 1alpha-hydroxy-1(4H)-isocadalen-4-one (6), 1alpha-hydroxy-4alphaH-1,2,3,4-tetrahydrocadalen-15-oic acid (7), 7-(3,3-dimethylallyloxy)coumarin, caryolan-1,9beta-diol, and quercetin. The structures of the new compounds were elucidated by spectroscopic methods. The antiinflammatory activities of the extracts and the isolated compounds were evaluated by determining the inhibition of TPA-induced mouse ear edema. The natural products 3, caryolan-1,9beta-diol, and quercetin were the most active substances tested and displayed dose-dependent activities.