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Comparison of NMDA and non-NMDA receptor antagonists-induced inhibition in hindpaw withdrawal response to noxious thermal stimulation
Ist Teil von
Sheng li hsüeh pao, 1998-06, Vol.50 (3), p.337
Ort / Verlag
China
Erscheinungsjahr
1998
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In our previous electrophysiological study, it was shown that NMDA receptors are predominantely involved in the transmission of nociceptive cutaneous afferents, whereas non-NMDA receptors are mainly concerned with the transmission of nociceptive muscular afferents. In the present investigation, the effects of NMDA and non-NMDA receptor antagonists were tested in rat hindpaw withdrawal response to noxious thermal stimulation. Intrathecal application of non-NMDA receptor antagonist 1 nmol/L DNQX (6,7-dinitroquinoxaline-2,3(1H, 4H)-dione) had no effect on paw withdrawal latencies (PWL), but NMDA receptor antagonist 1 nmol/L APV [(+/-) 2-amino-5-phosphonovalerate)] significantly prolonged PWL (P < 0.05). Both APV and DNQX at 10 nmol/L significantly increased PWL with the former agent being more potent. The results further support that both NMDA and non-NMDA receptors are involved in the transmission of spinal nociception, with the former being more preferentially involved in the transmission of nociceptive inform