Details

Autor(en) / Beteiligte

• Li, Xiaoxia
• Commane, Mairead
• Nie, Huiqin
• Hua, Xianxin
• Chatterjee-Kishore, Moitreyee
• Wald, David
• Haag, Michael
• Stark, George R.

Titel

Act1, an NF-κ B-activating Protein

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (19), p.10489-10493

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Use of an NF-κ B-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-κ B activator. Act1 associates with and activates Iκ B kinase (IKK), leading to the liberation of NF-κ B from its complex with NF-κ B. Many signaling pathways that liberate NF-κ B also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-κ B and JNK. Act1 fails to activate NF-κ B in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.