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1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines
Bioscience, biotechnology, and biochemistry, 2000-05, Vol.64 (5), p.1038-1040
2000

Details

Autor(en) / Beteiligte
Titel
1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines
Ist Teil von
  • Bioscience, biotechnology, and biochemistry, 2000-05, Vol.64 (5), p.1038-1040
Ort / Verlag
Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
  • Guided by their DPPH radical-scavenging activity, nine compounds were isolated from soybean miso. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and syringic acid had as high DPPH radical-scavenging activity as that of α-tocopherol. The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC 50 =5.2 μM) toward human promyelocytic leukemia cells (HL-60).
Sprache
Englisch
Identifikatoren
ISSN: 0916-8451
eISSN: 1347-6947
DOI: 10.1271/bbb.64.1038
Titel-ID: cdi_pubmed_primary_10879475
Format
–
Schlagworte
8-hydroxyisoflavone, AGENTES ANTINEOPLASTICOS, ALIMENT A BASE DE SOJA POUR HOMME, ALIMENTOS DERIVADOS DE LA SOJA, Animals, ANTINEOPLASTIC AGENTS, Antineoplastic Agents, Phytogenic - pharmacology, antiproliferative activity, Bepridil - analogs & derivatives, Biological and medical sciences, Biphenyl Compounds, cancer cell, Cell Division - drug effects, Coumaric Acids - metabolism, Coumaric Acids - pharmacology, DPPH radical-scavenging activity, Drug Screening Assays, Antitumor, Fermentation, FLAVONOIDE, FLAVONOIDES, FLAVONOIDS, Free Radical Scavengers - isolation & purification, Free Radical Scavengers - metabolism, Free Radical Scavengers - pharmacology, Free Radicals, General pharmacology, Genistein - metabolism, Genistein - pharmacology, Glycine max - chemistry, Glycine max - metabolism, Humans, Isoflavones - chemistry, Isoflavones - pharmacology, Medical sciences, MEDICAMENT CYTOSTATIQUE, Mice, NEOPLASMAS, NEOPLASME, NEOPLASMS, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Picrates, soybean miso, SOYFOODS, Tumor Cells, Cultured

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