Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2000-03, Vol.63 (2), p.60
2000
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Details
- Autor(en) / Beteiligte
- Titel
- The use of the fluorimetric method for studying DNA integrity exemplified by an assessment of dioxidine genotoxicity
- Ist Teil von
- Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2000-03, Vol.63 (2), p.60
- Ort / Verlag
- Russia (Federation)
- Erscheinungsjahr
- 2000
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The genotoxic effect of dioxidine (300, 100, 30, and 10 mg/kg, i.p.) on the liver cells of outbred male rats was studied by fluorometric analysis of DNA unwinding (FADU) using the cell DNA samples taken from animals sacrificed 1, 6, 18, and 24 h after drug introduction. At a dose of 10 mg/kg, dioxidine produced no statistically significant increase in the amount of DNA damage relative to control. Increase in the dioxidine dose to 30 mg/kg resulted in a significant DNA damage 1 h after drug administration, while a dose of 100 or 300 mg/kg reliably caused damage at all times of exposure.
- Sprache
- Russisch
- Identifikatoren
- ISSN: 0869-2092Titel-ID: cdi_pubmed_primary_10834098
- Format
- –
- Schlagworte
- Animals, DNA - analysis, DNA - drug effects, DNA - genetics, DNA Damage, Dose-Response Relationship, Drug, Fluorometry - methods, Fluorometry - statistics & numerical data, Genes - drug effects, Liver - chemistry, Liver - drug effects, Male, Mutagens - toxicity, Quinoxalines - toxicity, Rats, Time Factors