Details

Autor(en) / Beteiligte

• Kondo, K
• Sakamoto, J
• Nakazato, H
• Koike, A
• Kitoh, T
• Hachisuka, K
• Saji, S
• Yura, J
• Nimura, Y
• Hamajima, N
• Katoh, K
• Yamaguchi, A
• Miya, K I
• Yamauchi, M
• Mizuno, I
• Nagino, M
• Takagi, H

Titel

A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer

Ist Teil von

• Oncology reports, 2000-05, Vol.7 (3), p.485

Ort / Verlag

Greece

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• We conducted a phase III randomized study to investigate effects of supportive chemotherapy with oral doxifluridine (group A, 75 patients) or 5-fluorouracil (group B, 75 patients) in advanced gastric cancer when intensive chemotherapy was not an option. Although there were no significant differences between the groups with regard to survival, hospital-free survival and time to progression, median values of 3 endpoints were superior in group A. Secondary analysis showed that group A patients with prior chemotherapy tended to have longer survival and hospital-free survival and significantly longer time to progression.