Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Expression of urokinase and its receptor correlate with proliferation of smooth muscle cell in injured arteries
Ist Teil von
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2000-01, Vol.86 (1), p.18
Ort / Verlag
Russia (Federation)
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Using the immunohistochemistry and a standard reverse transcriptase-polymerase chain reaction assay optimized to estimate the mRNA levels, we observed a 2-fold increased uPA expression by the SMCs in injured vessels as compared with uninjured vessels. The uPA elevation occurred within 6 hours from the injury and persisted for 96 hours after the injury. The uPAR expression was also elevated after an injury although it occurred slower and more gradually. The data obtained suggest that the uPA is capable of contributing to both the SMC migration, replication and accumulation in the neointima early after balloon catheter injury of the carotid artery in rats.