Details

Autor(en) / Beteiligte

• Pierrefite-Carle, V
• Baque, P
• Gavelli, A
• Benchimol, D
• Bourgeon, A
• Milano, G
• Saint-Paul, M C
• Rossi, B

Titel

Regression of experimental liver tumor after distant intra-hepatic injection of cytosine deaminase-expressing tumor cells and 5-fluorocytosine treatment

Ist Teil von

• International journal of molecular medicine, 2000-03, Vol.5 (3), p.275

Ort / Verlag

Greece

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• Cytosine deaminase (CD) gene of E. coli converts the non-toxic compound 5-fluorocytosine (5-FC) into 5-fluorouracil. We have introduced a vector expressing the CD gene in a rat colon carcinoma cell line. Expression of the CD gene confers 5-FC sensitivity to these cells in vitro and in vivo. In a bifocal model consisting in a simultaneous engrafment of a CD+ tumor on one lobe of the liver and a wild-type parental tumor on the opposite lobe, treatment with 5-FC results in regression of both type of tumors, indicating the existence of a distant bystander effect.