Details

Autor(en) / Beteiligte

• Lim, L C
• Heng, K K
• Vellupillai, M
• Tan, L T
• Boey, B C
• Lau, L C
• How, G F

Titel

Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia

Ist Teil von

• International journal of molecular medicine, 1999-12, Vol.4 (6), p.665

Ort / Verlag

Greece

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• The Philadelphia chromosome is present in a heterogeneous group of leukemias. It is most commonly associated with chronic myelogenous leukemia (CML) and B-lineage acute lymphoblastic leukemia (ALL) being found in more than 95% and 15-25% of cases respectively. We undertook a study to determine the morphologic, phenotypic and molecular diversity of Philadelphia positive de novo acute leukemia patients seen at our institution over the past 3 1/2 years. Twenty-one patients with de novo acute leukemia were found to have the Philadelphia chromosome by cytogenetic studies. They consisted of 3 patients with acute myelogenous leukemia (AML), 1 biphenotypic leukemia and 17 ALL patients. Of the patients with ALL, 16 were of B-lineage while 1 had a T-cell phenotype. Ten patients expressed the p210 BCR-ABL transcript alone and 10 expressed only the p190 BCR-ABL transcript. One patient had co-expression of p190 and p210 b3a2 BCR-ABL transcripts. Thus the Philadelphia chromosome can be found in a diverse cohort of morphologic and immunologic subtypes of de novo acute leukemia reflecting the heterogeneity of lineage involvement in this disease.