Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Internal Radionuclide Therapy of Primary Osteosarcoma in Dogs, Using 153Sm-Ethylene-diamino-tetramethylene-phosphonate (EDTMP)
Ist Teil von
Clinical cancer research, 1999-10, Vol.5 (10), p.3148s
Ort / Verlag
United States: American Association for Cancer Research
Erscheinungsjahr
1999
Quelle
MEDLINE
Beschreibungen/Notizen
Fifteen dogs were referred because of a spontaneous bone tumor, lameness, and local pain. The osteosarcoma diagnosis was established
by clinical examination, X-ray, bone scintigraphy, and histological examination of biopsy material. The tumors were located
in the extremities ( n = 12), scapula ( n = 1), maxilla ( n = 1), and the frontal bone ( n = 1). The dogs were given one to four i.v. injections of 153 Sm-labeled ethylene-diamino-tetramethylene-phosphonate ( 153 Sm-EDTMP; 36–57 MBq/kg body weight). Three dogs had surgery in addition to the radionuclide treatment. Platelet and WBC counts
showed a moderate and transient decrease. No other toxicity was observed. Average tumor doses after a single injection were
∼20 Gy, considerably higher in some areas because of inhomogeneous uptake. Macroscopically distant metastases were detected
in seven dogs at autopsy. One dog died from an intercurrent disease, free of cancer, 5 months after the radionuclide treatment.
None of the dogs was cured. The median and mean survival times from the first treatment to death or euthanasia were 150 and
252 days, respectively. Nine of the dogs had obvious pain relief, and five of them seemed pain-free: one for 20 months and
one for 48 months. It is concluded that high tumor doses may be deposited in dog osteosarcomas by 153 Sm-EDTMP, and the ratio between tumor dose and the dose to surrounding tissues is favorable. The treatment gives pain relief
and in some cases tumor growth delay. In combination with surgery, 153 Sm-EDTMP may prolong life significantly and possibly cure the disease because the development of metastases are seemingly
postponed. No serious side effects were observed.