Details

Autor(en) / Beteiligte

• Schondorf, T
• Andrack, A
• Niederacher, D
• Scharl, A
• Becker, M
• Engel, H
• Gohring, U J

Titel

H-ras gene amplification or mutation is not common in human primary breast cancer

Ist Teil von

• Oncology reports, 1999-09, Vol.6 (5), p.1029

Ort / Verlag

Greece

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• In a clinical study we found that patients with primary node negative breast cancer whose tumors showed high expression of H-ras had a significantly better prognosis than patients whose carcinomas did not. In the present study, these tissue specimens showed no H-ras gene mutation. The rate of gene amplification was 5% and did not correlate with the level of H-ras expression. These data indicate that increased expression and not amplification of the H-ras gene is valuable, if H-ras has a favorable role with respect to clinical outcome. This might be a general protective reaction as long as no mutation event has occurred in the H-ras gene.