Details

Autor(en) / Beteiligte

• Saggau, W
• Bleyl, U
• Brückner, U B
• Klöss, T
• Leinberger, H
• Metzker, M
• Schmier, J

Titel

Pulmonary hemodynamics, coagulation and morphological changes in the lung after thrombocyte aggregation inhibition and intravasal coagulation in experimental trauma and hemorrhagic shock

Ist Teil von

• Langenbecks Archiv für Chirurgie, 1976, Vol.Suppl, p.322

Ort / Verlag

Germany

Erscheinungsjahr

1976

Quelle

MEDLINE

Beschreibungen/Notizen

• 26 mongrel dogs are subjected to a standardized bone trauma followed by a hypotonic hemorrhagic shock. Compared with a control and heparin group prophylactic treatment with Dipyridamol and Acetylsalicylic Acid decreases pulmonary vascular resistance significantly. After an initial period of hyperocagulability secondary fibrinolysis develops. The decrease of the fibrinogen level and the fall of total platelet count after trauma and hemorrhage can partly be prevented by the application of heparin, likewise the development of pulmonary microthrombosis. Histological examination shows a markedly diminished pulmonary microthrombosis.