Details

Autor(en) / Beteiligte

• Grant, J. Andrew
• Danielson, Linda
• Rihoux, Jean-Pierre
• DeVos, Christine

Titel

A Comparison of Cetirizine, Ebastine, Epinastine, Fexofenadine, Terfenadine, and Loratadine versus Placebo in Suppressing the Cutaneous Response to Histamine

Ist Teil von

• International archives of allergy and immunology, 1999-02, Vol.118 (2-4), p.339-340

Ort / Verlag

Basel, Switzerland: Karger

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• From Molecular Science to the Treatment of Allergy First discovered over 60 years ago, H1-antihistamines have developed a fundamental role for management of allergic disorders. The second-generation drugs offer advantages of greater potency and reduced side effects. Simons et al. [1] compared these drugs and showed the order of potency for blocking the wheal and flare response to histamine in the skin was cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine. Juhlin [2] reviewed multiple clinical trials showing superiority for cetirizine. Recently, new H1-antagonists have become available, but there has been no comparison of their potency.