Details

Autor(en) / Beteiligte

• Korolenko, T A
• Kaledin, V I
• Svechnikova, I G
• Li, X V
• Stashko, J F
• Ilnitskaya, S I
• Nikolin, V P

Titel

Study of the antitumor effect of Ukrain: the role of macrophage secretion of alpha-1-proteinase inhibitor

Ist Teil von

• Drugs under experimental and clinical research, 1998, Vol.24 (5-6), p.271

Ort / Verlag

Switzerland

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• The positive antitumor effect of Ukrain was shown following i.m. injection of a mixture of this drug with Krebs-2 carcinoma cells to CBA mice. The protective effect was suggested to be a result of the influx of macrophages into the site of Ukrain injection. In contrast, contralateral administration of Ukrain had a negative effect, confirming our hypothesis that Ukrain attracts cytolytic macrophages. In the murine HA-1 hepatoma model treated by single or repeated Ukrain injections, a moderate positive effect of Ukrain was related to increased macrophage (alpha-1-proteinase inhibitor (PI) secretion. The role of tumor cells and macrophages in the secretion of PI (the main inhibitor of serine proteinases) during tumor development is discussed.