Details

Autor(en) / Beteiligte

• Heckler, Ilana
• Bojmehrani, Azadeh
• Hegde, Madhuri

Titel

Molecular genetic testing for autoimmune diseases

Ist Teil von

• MLO. Medical laboratory observer, 2022-04, Vol.54 (4), p.8-12

Ort / Verlag

Nashville: Endeavor Business Media

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• [...]in cases where CD patients are on a gluten-free diet, who therefore have very low CD-specific antibody titers, genetic testing is a useful option.3 Using DNA microarray solutions, the identification of the disease-associated alleles HLA-DQA1- and HLA-DQB1, which code for the subunits HLA-DQ2.2, -DQ2.5 and -DQ8, can be done.4 Such microarray testing can differentiate between the Earning CEUs See test on page 13 oronline atwww.mlo-online.com under the CE Tests tab. Discuss how HLA genotyping plays a role in solid organ transplantation, hematopoietic stem cell transplantation, and transfusion practice for platelet refractoriness patients.15 homozygous and heterozygous presence of the alleles that code the alpha and beta subunits of HLA-DQ2.2 and -DQ2.5, which enables improved risk assessment in the case of a positive HLA-DQ2 result.4 HLA-DRB1 in rheumatoid arthritis Rheumatoid Arthritis (RA) is a chronic autoimmune disease that causes joint pain, stiffness, swelling and decreased joint motility and affects an estimated 1.28-1.36 million Americans.5 RA is considered to develop because of interactions between genetic factors and environmental factors. HLA-Cw6 has been shown to have an impact on illness progression, phenotypic traits, severity, comorbidities, and treatment outcomes on numerous occasions.1213 DNA microarrays are a proven method for accurately detecting HLA-Cw6.4 Using a blood sample, the HLA-Cw6 gene can be tested. Autoimmune diseases are characterized by immune system dysfunction leading to the loss of tolerance to self-antigens, presence of increased level of autoantibodies, inflammatory and mediatory cells thereby leading to chronic inflammation14.Multiple studies have been published demonstrating evidence common genetic etiology in ADs.These studies have shown evidence of clustering of multiple autoimmune diseases in families and in individuals, associated with genetic regions predisposing to several autoimmune diseases primarily through GWAS.