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Though 2021 was another tough year, it also brought some spots of joy—including visually arresting, thought-provoking, and inspiring reference works, as exhibited in these 37 stellar examples selected by the LJ Best Reference committee. With COVID still raging, health is top of mind; Joseph P. Byrne and Jo N. Hays's Epidemics and Pandemics: From Ancient Plagues to Modern-Day Threats reminds readers that contagious disease has long been a part of human history, while The Medicine Book explores the great strides humanity has made coping with it, including the development of vaccines.