Details

Autor(en) / Beteiligte

• Pichichero, Michael E

Titel

The latest word on penicillin allergy

Ist Teil von

• Drug Topics, 2005-07, Vol.149 (14), p.18

Ort / Verlag

Monmouth Junction: MJH Life Sciences Media

Erscheinungsjahr

2005

Quelle

EBSCOhost Business Source Ultimate

Beschreibungen/Notizen

• A physician discusses in detail the possibility of allergic cross-reactivity between penicillin and cephalosporin antibiotics. Despite a myriad of studies over the past several decades using varied patient populations, the true increased risk of an allergic reaction to a cephalosporin in a patient with a penicillin allergy compared with a primary (and unrelated) cephalosporin allergy has not been clearly established. The rate of cross-reactivity between penicillin and most second-, third-, and fourth-generation cephalosporins is low and may actually be lower than that between penicillins and other classes of antibiotics. As a rule, the cross-allergy risk from first-generation cephalosporins is about 0.5%, and the risk from second-generation or third-generation cephalosporins is near zero. Tables giving risk values with various cephalosporins under various circumstances are provided.