Bone marrow transplantation (Basingstoke), 2012-01, Vol.47 (1), p.88-94
2012
Details
- Autor(en) / Beteiligte
- Titel
- The clinical features and outcome of 2009 H1N1 influenza infection in Allo-SCT patients: a British Society of Blood and Marrow Transplantation study
- Ist Teil von
- Bone marrow transplantation (Basingstoke), 2012-01, Vol.47 (1), p.88-94
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0268-3369eISSN: 1476-5365DOI: 10.1038/bmt.2011.12Titel-ID: cdi_proquest_miscellaneous_968170730
- Format
- –
- Schlagworte
- Adolescent, Adult, Age, Age Factors, Aged, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Biological and medical sciences, Blood, Bone marrow, Bone Marrow Transplantation, Bone marrow, stem cells transplantation. Graft versus host reaction, Child, Child, Preschool, Cohort Studies, Critical Care, Data processing, Development and progression, Diagnosis, Disease-Free Survival, Female, Geriatrics, Health aspects, Human viral diseases, Humans, Immunodeficiencies, Immunodeficiencies. Immunoglobulinopathies, Immunopathology, Infant, Infectious diseases, Influenza, Influenza A Virus, H1N1 Subtype, Influenza, Human - mortality, Influenza, Human - therapy, Intensive care units, Lung diseases, Male, Medical sciences, Middle Aged, Morbidity, Mortality, Pandemics, Patient outcomes, Pneumonia, Pneumonia - mortality, Pneumonia - therapy, Risk factors, Societies, Medical, Stem Cell Transplantation, Stem cells, Survival Rate, Swine influenza, Time Factors, Transfusions. Complications. Transfusion reactions. Cell and gene therapy, Transplantation, Transplantation, Homologous, United Kingdom, United Kingdom - epidemiology, Viral diseases, Viral diseases of the respiratory system and ent viral diseases