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Journal of materials chemistry, 2011-01, Vol.21 (42), p.16717-16734
Erscheinungsjahr
2011
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Both function and use of nanoparticles (NPs) to a great extent are dominated by interfacial energies, which in turn can be addressed by chemical modifications. This article focuses exclusively on the use of 'click'-chemistry for NP-surface modification, also putting a major focus on the application of the resulting NPs in bio- and nanoscience. As 'click'-chemistry is a universal method to link reaction partners in high efficiency, solvent insensitivity and at moderate reaction conditions, its use for engineering NP surfaces has become widespread. The basic approach of Cu(i)-catalyzed azide/alkyne-'click' (CuAAC) chemistry for NP-science is elucidated in this article, together with the applications of the resulting surface modified NPs in medicine, nanotechnology and bioassay-science.