Details

Autor(en) / Beteiligte

• Schnyder, Benno, MD
• Pichler, Werner J., MD

Titel

Nonimmediate drug allergy: Diagnostic benefit of skin testing and practical approach

Ist Teil von

• Journal of allergy and clinical immunology, 2012-04, Vol.129 (4), p.1170-1171

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• [...]it is well documented that some nonimmediate reactions appear only after a treatment of several days at full therapeutic dosage.3 Furthermore, cofactors, such as concomitant viral infections, are considered important, and these are normally not present during challenge tests. [...]only a positive test result is conclusive, and even challenge tests are not an unequivocal gold standard. According to the data currently available, the sensitivity (and also negative likelihood ratio) of skin tests is only moderate, and thus a negative skin test result does not exclude the diagnosis of a nonimmediate drug allergy.