Details

Autor(en) / Beteiligte

• MINNERUP, Jens
• ANDREAS RITTER, Martin
• DZIEWAS, Rainer
• WERSCHING, Heike
• KEMMLING, André
• OKEGWO, Angelika
• SCHMIDT, Antje
• SCHILLING, Matthias
• BERND RINGELSTEIN, E
• SCHABITZ, Wolf Riidiger
• YOUNG, Peter

Titel

Continuous Positive Airway Pressure Ventilation for Acute Ischemic Stroke: A Randomized Feasibility Study

Ist Teil von

• Stroke (1970), 2012-04, Vol.43 (4), p.1137-1139

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Sleep-related breathing disorders occur frequently after stroke. We assessed the feasibility of continuous positive airway pressure (CPAP) treatment initiated in the first night after stroke. In this open-label, parallel-group trial, 50 patients were randomly assigned to the CPAP therapy or to the control group. All patients underwent polysomnography in the fourth night. Intervention patients received CPAP therapy for 3 nights starting the first night after stroke onset and for an additional 4 nights when polysomnography revealed an apnea-hypopnea index >10/hour. The primary end point was feasibility defined as apnea-hypopnea index reduction under CPAP treatment, nursing workload, and CPAP adherence. The apnea-hypopnea index under CPAP treatment was significantly reduced (32.2±25.3-9.8±6.6, P=0.0001). Nursing workload did not significantly differ between the CPAP (n=25) and the control group (n=25; P=0.741). Ten patients (40.0%) had excellent CPAP use, 14 patients (56.0%) had some use, and 1 patient (4.0%) had no use. There was a trend toward greater National Institutes of Health Stroke Scale score improvement until Day 8 in patients on CPAP (2.00 versus 1.40, P=0.092) and a significantly greater National Institutes of Health Stroke Scale score improvement in patients with excellent CPAP use when compared with control patients (2.30 versus 1.40, P=0.022). CPAP therapy initiated in the first night after stroke seems to be feasible and was not associated with neurological deterioration. Clinical Trial Registration- URL: www.clinicaltrials.gov. Unique identifier: NCT00151177.