Prion, 2012-01, Vol.6 (1), p.89-93
2012
Details
- Autor(en) / Beteiligte
- Titel
- Comparative analysis of Japanese and foreign L-type BSE prions
- Ist Teil von
- Prion, 2012-01, Vol.6 (1), p.89-93
- Ort / Verlag
- United States: Landes Bioscience
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- L-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE. To characterize the Japanese L-type BSE prion, we conducted a comparative study of the Japanese and foreign L-type BSE isolates. The L-type BSE isolates of Japan, Germany, France and Canada were intracerebrally inoculated into bovinized prion protein-overexpressing transgenic mice (TgBoPrP). All the examined L-type BSE isolates were transmitted to TgBoPrP mice, and no clear differences were observed in their biological and biochemical properties. Here, we present evidence that the Japanese and Canadian L-type BSE prions are identical to those from the European cases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1933-6896eISSN: 1933-690XDOI: 10.4161/pri.6.1.18429Titel-ID: cdi_proquest_miscellaneous_959128545
- Format
- –
- Schlagworte
- Animals, Binding, Biology, Bioscience, Blotting, Western, Brain - metabolism, Brain - pathology, Calcium, Cancer, Cattle, Cell, Cycle, Encephalopathy, Bovine Spongiform - epidemiology, Encephalopathy, Bovine Spongiform - metabolism, Encephalopathy, Bovine Spongiform - transmission, Endopeptidase K - metabolism, Japan - epidemiology, Landes, Mice, Mice, Transgenic, Organogenesis, Prions - metabolism, Proteins, Short Communication