Details

Autor(en) / Beteiligte

• Shi, Chenggang
• Huang, Jiyi
• Liu, Xun
• Zeng, Xiaolin
• Cheng, Cailian
• Yin, Qiongli
• Li, Mei
• Cheng, Guifeng

Titel

Diagnostic significance of hepatitis B viral antigens in patients with glomerulonephritis-associated hepatitis B virus infection

Ist Teil von

• Diagnostic microbiology and infectious disease, 2012-02, Vol.72 (2), p.156-160

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Hepatitis B viral infection can lead to hepatitis B virus–associated glomerulonephritis, a clinically significant subtype of secondary nephritis. In the present study, we examined the presence of PreS1/S2 antigen in renal tissues by use of immunohistochemistry and investigated the use of PreS1/S2 and 2 HBV serum antigens, HBe-Ag and HBs-Ag, in the diagnosis. We assessed the presence of these 3 antigens in patients with confirmed hepatitis B virus–associated glomerulonephritis ( n = 22) and patients without this disease ( n = 19). Our results indicate that the combined use of PreS1/S2-Ag and serum HBe-Ag in the diagnosis of hepatitis B virus–associated glomerulonephritis had good positive predictive value (0.89), modest negative predictive value (0.77), and substantial agreement based on Cohen's kappa coefficient ( κ = 0.660, P < 0.001). We suggest that our results be considered in the development of more definitive diagnostic criteria for hepatitis B virus–associated glomerulonephritis.