Details

Autor(en) / Beteiligte

• Brambilla, Paolo
• Nicoletti, Mark A
• Harenski, Keith
• Sassi, Roberto B
• Mallinger, Alan G
• Frank, Ellen
• Kupfer, David J
• Keshavan, Matcheri S
• Soares, Jair C

Titel

Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects

Ist Teil von

• Neuropsychopharmacology (New York, N.Y.), 2002-11, Vol.27 (5), p.792-799

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p > .05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial.