Details

Autor(en) / Beteiligte

• Cobb, Joanna E.
• Zaloumis, Sophie G.
• Scurrah, Katrina J.
• Harrap, Stephen B.
• Ellis, Justine A.

Titel

Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene

Ist Teil von

• Experimental dermatology, 2010-11, Vol.19 (11), p.1026-1028

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2010

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Please cite this paper as: Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene. Experimental Dermatology 2010; 19: 1026–1028. :  The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia – AGA). In case–control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA (P = 3.75 × 10−5) in 1195 men. We also replicated association with a recently reported non‐coding region on chromosome 20 and found that its association with AGA was less strong and independent of that of AR. Our results will help focus future efforts to further define AGA genetic risk.