Details

Autor(en) / Beteiligte

• Bénard, Giovanni
• Massa, Federico
• Puente, Nagore
• Lourenço, Joana
• Bellocchio, Luigi
• Soria-Gómez, Edgar
• Matias, Isabel
• Delamarre, Anna
• Metna-Laurent, Mathilde
• Cannich, Astrid
• Hebert-Chatelain, Etienne
• Mulle, Christophe
• Ortega-Gutiérrez, Silvia
• Martín-Fontecha, Mar
• Klugmann, Matthias
• Guggenhuber, Stephan
• Lutz, Beat
• Gertsch, Jürg
• Chaouloff, Francis
• López-Rodríguez, María Luz
• Grandes, Pedro
• Rossignol, Rodrigue
• Marsicano, Giovanni

Titel

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

Ist Teil von

• Nature neuroscience, 2012-03, Vol.15 (4), p.558-564

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Psychology & Behavioral Sciences Collection

Beschreibungen/Notizen

• The mammalian brain is one of the organs with the highest energy demands, and mitochondria are key determinants of its functions. Here we show that the type-1 cannabinoid receptor (CB(1)) is present at the membranes of mouse neuronal mitochondria (mtCB(1)), where it directly controls cellular respiration and energy production. Through activation of mtCB(1) receptors, exogenous cannabinoids and in situ endocannabinoids decreased cyclic AMP concentration, protein kinase A activity, complex I enzymatic activity and respiration in neuronal mitochondria. In addition, intracellular CB(1) receptors and mitochondrial mechanisms contributed to endocannabinoid-dependent depolarization-induced suppression of inhibition in the hippocampus. Thus, mtCB(1) receptors directly modulate neuronal energy metabolism, revealing a new mechanism of action of G protein-coupled receptor signaling in the brain.