Annual review of immunology, 2012-01, Vol.30 (1), p.203-220
2012
Details
- Autor(en) / Beteiligte
- Titel
- VLR-Based Adaptive Immunity
- Ist Teil von
- Annual review of immunology, 2012-01, Vol.30 (1), p.203-220
- Ort / Verlag
- United States: Annual Reviews
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Lampreys and hagfish are primitive jawless vertebrates capable of mounting specific immune responses. Lampreys possess different types of lymphocytes, akin to T and B cells of jawed vertebrates, that clonally express somatically diversified antigen receptors termed variable lymphocyte receptors (VLRs), which are composed of tandem arrays of leucine-rich repeats. The VLRs appear to be diversified by a gene conversion mechanism involving lineage-specific cytosine deaminases. VLRA is expressed on the surface of T-like lymphocytes; B-like lymphocytes express and secrete VLRB as a multivalent protein. VLRC is expressed by a distinct lymphocyte lineage. VLRA-expressing cells appear to develop in a thymus-like tissue at the tip of gill filaments, and VLRB-expressing cells develop in hematopoietic tissues. Reciprocal expression patterns of evolutionarily conserved interleukins and chemokines possibly underlie cell-cell interactions during an immune response. The discovery of VLRs in agnathans illuminates the origins of adaptive immunity in early vertebrates.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0732-0582eISSN: 1545-3278DOI: 10.1146/annurev-immunol-020711-075038Titel-ID: cdi_proquest_miscellaneous_953208942
- Format
- –
- Schlagworte
- Adaptive Immunity, Animals, antigen receptor, Antigens - immunology, Antigens - metabolism, Biological Evolution, Cell Differentiation - genetics, Cell Differentiation - immunology, Cell interactions, Cell Lineage - genetics, Cell Lineage - immunology, Chemokines, Cytosine deaminase, Cytosine Deaminase - genetics, Evolution, Filaments, Gene Expression, Gene Expression Profiling, Gills, Hemopoiesis, Humans, Immune response, Immunity, Interleukins, jawless vertebrate, leucine-rich repeat, lymphocyte lineage, Lymphocytes - cytology, Lymphocytes - immunology, Lymphocytes - metabolism, Lymphocytes B, Lymphocytes T, Myxinidae, Petromyzontidae, Protein Binding - immunology, Protein Conformation, Receptors, Antigen - chemistry, Receptors, Antigen - genetics, Receptors, Antigen - immunology, Reviews, somatic diversification