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Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells
Journal of the science of food and agriculture, 2012-04, Vol.92 (6), p.1273-1281
Tumbas, Vesna T
Čanadanović-Brunet, Jasna M
Četojević-Simin, Dragana D
Ćetković, Gordana S
Ðilas, Sonja M
Gille, Lars
2012
Details
Autor(en) / Beteiligte
Tumbas, Vesna T
Čanadanović-Brunet, Jasna M
Četojević-Simin, Dragana D
Ćetković, Gordana S
Ðilas, Sonja M
Gille, Lars
Titel
Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells
Ist Teil von
Journal of the science of food and agriculture, 2012-04, Vol.92 (6), p.1273-1281
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library Database Model
Beschreibungen/Notizen
BACKGROUND: The commercial development of plants as sources of antioxidants that can be used to enhance the properties of foods, for nutritional purposes and preservation as well as for prevention of oxidation‐related diseases, is currently of major interest. Rosehip (Rosa canina L.) is a rich source of vitamin C and polyphenols. RESULTS: Phytochemicals in rosehip tea were separated into three fractions: Fr1 (vitamin C, 39.17 mg kg−1), Fr2 (flavonoids, 451.05 µg kg−1) and Fr3 (phenolic acids, 504.69 µg kg−1). Quercetin and ellagic acid were the most abundant polyphenolic compounds. Rosehip fractions, primarily rosehip flavonoids (EC50 = 49 mg L−1), showed high antioxidant activity towards 2,2‐diphenyl‐1‐picrylhydrazyl radicals (DPPH•). Cell growth effects of rosehip fractions were assessed in HeLa, MCF7 and HT‐29 cell lines, with the lowest IC50 values being determined for rosehip flavonoids, (80.63, 248.03 and 363.95 mg L−1 respectively). However, the vitamin C fraction did not inhibit the growth of tested tumour cells. CONCLUSION: The results of this study confirm that vitamin C and flavonoids are responsible for the antioxidant activity of rosehip tea, while only polyphenols contribute to its antiproliferative activity. Copyright © 2011 Society of Chemical Industry
Sprache
Englisch
Identifikatoren
ISSN: 0022-5142
eISSN: 1097-0010
DOI: 10.1002/jsfa.4695
Titel-ID: cdi_proquest_miscellaneous_929506961
Format
–
Schlagworte
Antineoplastic Agents, Phytogenic - chemistry
,
Antineoplastic Agents, Phytogenic - pharmacology
,
Antineoplastic Agents, Phytogenic - therapeutic use
,
antioxidant activity
,
Antioxidants
,
Antioxidants - analysis
,
Antioxidants - pharmacology
,
antiproliferative activity
,
Ascorbic Acid - pharmacology
,
Biological and medical sciences
,
Biphenyl Compounds - metabolism
,
Cell Line, Tumor
,
Ellagic Acid - analysis
,
flavonoid
,
Flavonoids - analysis
,
Flavonoids - pharmacology
,
Food industries
,
Food science
,
Free Radicals - metabolism
,
Fruit - chemistry
,
Fundamental and applied biological sciences. Psychology
,
HeLa Cells
,
Humans
,
Inhibitory Concentration 50
,
Neoplasms - drug therapy
,
Neoplasms - metabolism
,
Oxidation
,
phenolic acid
,
Phytochemicals
,
Phytotherapy
,
Picrates - metabolism
,
Plant Extracts - chemistry
,
Plant Extracts - pharmacology
,
Plant Extracts - therapeutic use
,
Polyphenols
,
Polyphenols - analysis
,
Polyphenols - pharmacology
,
Quercetin - analysis
,
Rosa - chemistry
,
rosehip
,
vitamin C
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