Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2460-2463
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2460-2463
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against cancer cells only but not on normal cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2012.02.011Titel-ID: cdi_proquest_miscellaneous_929123264
- Format
- –
- Schlagworte
- Antineoplastic Agents - chemical synthesis, Antineoplastic Agents - pharmacology, Biological and medical sciences, Cancer, Catalysis, Cell Line, Tumor, Cell Survival - drug effects, Condensation, Cytotoxicity, Di(indolyl)indolin-2-one, Humans, Indole, Indoles, Indoles - chemistry, Inhibitory Concentration 50, Iodine, Iodine - chemistry, Isatin, Isatin - chemistry, Medical sciences, Molecular iodine, Molecular Structure, Organ Specificity, Pharmacology. Drug treatments