Nutrition (Burbank, Los Angeles County, Calif.), 2012-04, Vol.28 (4), p.458-464
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Effects of a normolipidic diet containing trans fatty acids during perinatal period on the growth, hippocampus fatty acid profile, and memory of young rats according to sex
- Ist Teil von
- Nutrition (Burbank, Los Angeles County, Calif.), 2012-04, Vol.28 (4), p.458-464
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2012
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Abstract Objective To investigate whether dietary trans fatty acids (TFAs) are incorporated in the hippocampus and its effects on the growth and aversive and spatial memories of young rats. Methods Wistar rat offspring whose mothers were fed with normolipidic diets containing soybean oil (soy group) or hydrogenated vegetable oil ( trans group) during gestation and lactation were used. Male and female pups received the same diets as their mothers until the end of behavioral testing. The composition of fatty acids in the total lipids of the diets and hippocampus was quantified by gas chromatography. The results were evaluated by Student’s t test or analysis of variance followed by the Bonferroni correction. Results The trans male and female body weights were higher during lactation and after weaning, with trans males having the lower body weight of the two. There was incorporation of 0.11% and 0.17% of TFAs in the hippocampi of male and female rats, respectively. During passive avoidance test, there was no significant difference. In the water maze test, there was no significant difference between male groups in the training and retention phases, except on day 4, when there was a significant decrease in latency in trans males. Trans females were worse on day 2 only and showed an improvement in spatial memory during the probe trial. Conclusion The TFAs were incorporated in small amounts in the hippocampus and did not affect aversive memory. However, spatial memory was modified in young rats fed with a diet rich in TFAs. These findings suggested that, in addition to the TFA content of the diet provided, it is important to consider the provision of essential fatty acids and the ω-6/ω-3 ratio.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0899-9007eISSN: 1873-1244DOI: 10.1016/j.nut.2011.08.007Titel-ID: cdi_proquest_miscellaneous_928375768
- Format
- –
- Schlagworte
- Animals, Aversive and spatial memories, Avoidance Learning - drug effects, Biological and medical sciences, Body weight, Body Weight - drug effects, Diet, Dietary Fats - metabolism, Dietary Fats - pharmacology, Dietary trans fatty acids, Fatty acids, Fatty Acids - metabolism, Fatty Acids - pharmacology, Feeding. Feeding behavior, Female, Fundamental and applied biological sciences. Psychology, Gas chromatography, Gastroenterology and Hepatology, Growth - drug effects, Hippocampal fatty acids, Hippocampus - drug effects, Hippocampus - metabolism, Lactation, Lipids, Male, Maze Learning - drug effects, Memory - drug effects, Morris water maze, Nutrition, Offspring, Passive avoidance, Plant Oils - administration & dosage, Plant Oils - metabolism, Pregnancy, Prenatal Exposure Delayed Effects, Prenatal Nutritional Physiological Phenomena, Rats, Rodents, Sex Factors, Soybean oil, Soybeans, Studies, Trans fats, Trans Fatty Acids - metabolism, Trans Fatty Acids - pharmacology, Variance analysis, Vegetable oils, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Weaning