Details

Autor(en) / Beteiligte

• Sakurai, Takuya
• Ogasawara, Junetsu
• Kizaki, Takako
• Ishibashi, Yoshinaga
• Fujiwara, Tomonori
• Akagawa, Kimio
• Izawa, Tetsuya
• Oh-ishi, Shuji
• Haga, Shukoh
• Ohno, Hideki

Titel

Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training

Ist Teil von

• Biochemical and biophysical research communications, 2011-12, Vol.416 (1), p.125-129

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• ► We examined effects of exercise training on cognitive impairment in SAMP8 mice. ► Exercise training attenuated impaired contextual fear memory in SAMP8 mice. ► Expression of the Lztfl1 mRNA in hippocampus was upregulated by exercise training. ► The overexpression of Lztfl1 promoted neurite outgrowth in Neuro 2a cells. ► Exercise induced increase in Lztfl1 is thought to indicate neurite outgrowth. It is well known that exercise prevents and reduces cognitive impairment. In the present study, we focused on exercise training as a tool to prevent cognitive impairment, and searched for novel molecules that may relate to the prevention of cognitive impairment in the hippocampus. Two-month-old senescence-accelerated mouse prone-8 (SAMP8) mice were subjected to voluntary exercise training by running on a wheel for 4 months, and were then assigned a conditioned fear memory test. Moreover, various mRNA levels in the hippocampus were examined by DNA array analysis and real-time PCR. Contextual fear memory in SAMP8 control mice was significantly impaired compared with that in non-senescence mice. Exercise training definitely attenuated such cognitive impairment. The results of real-time PCR analysis that was conducted following DNA array analysis in the hippocampus revealed that, compared with SAMR8 control mice, the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training. In addition, the overexpression of Lztfl1 promoted neurite outgrowth in Neuro 2a cells. These results suggest that exercise has a preventive effect on cognitive impairment in SAMP8 mice, and that exercise-induced increase in Lztfl1 induces neurite outgrowth.