Trends in parasitology, 2012-01, Vol.28 (1), p.23-30
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
- Ist Teil von
- Trends in parasitology, 2012-01, Vol.28 (1), p.23-30
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum . It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4922eISSN: 1471-5007DOI: 10.1016/j.pt.2011.10.002Titel-ID: cdi_proquest_miscellaneous_926887907
- Format
- –
- Schlagworte
- Animals, antibodies, antigens, Biological and medical sciences, erythrocytes, Erythrocytes - immunology, Erythrocytes - metabolism, Erythrocytes - parasitology, Gastroenterology and Hepatology, General aspects, Human protozoal diseases, Humans, immunity, Infectious Disease, Infectious diseases, Life Cycle Stages - immunology, Malaria, Malaria Vaccines - immunology, Malaria Vaccines - metabolism, Malaria, Falciparum - prevention & control, Medical sciences, parasites, Parasitic diseases, parasitology, Plasmodium falciparum, Plasmodium falciparum - immunology, Plasmodium falciparum - metabolism, Plasmodium falciparum - pathogenicity, proteins, Protozoal diseases, Protozoan Proteins - immunology, Protozoan Proteins - metabolism, Reticulocytes - immunology, Reticulocytes - metabolism, vaccines