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Physionomics and metabolomics-two key approaches in herbicidal mode of action discovery
Pest management science, 2012-04, Vol.68 (4), p.494-504
Grossmann, Klaus
Christiansen, Nicole
Looser, Ralf
Tresch, Stefan
Hutzler, Johannes
Pollmann, Stephan
Ehrhardt, Thomas
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Grossmann, Klaus
Christiansen, Nicole
Looser, Ralf
Tresch, Stefan
Hutzler, Johannes
Pollmann, Stephan
Ehrhardt, Thomas
Titel
Physionomics and metabolomics-two key approaches in herbicidal mode of action discovery
Ist Teil von
Pest management science, 2012-04, Vol.68 (4), p.494-504
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
BACKGROUND: For novel herbicides identified in greenhouse screens, efficient research is important to discover and chemically optimise new leads with new modes of action (MoAs). RESULTS: The metabolic and physiological response pattern to a herbicide can be viewed as the result of changes elicited in the molecular and biochemical process chain. These response patterns are diagnostic of a herbicide's MoA. At the starting point of MoA characterisation, an array of bioassays is used for comprehensive physiological profiling of herbicide effects. This physionomics approach enables discrimination between known, novel or multiple MoAs of a compound and provides a first clue to a new MoA. Metabolic profiling is performed with the use of treated Lemna paucicostata plants. After plant extraction and chromatography and mass spectrometry, changes in levels of approximately 200 identified and 300 unknown analytes are quantified. Check for known MoA assignment is performed by multivariate statistical data analyses. Distinct metabolite changes, which can direct to an affected enzymatic step, are visualised in a biochemical pathway view. Subsequent target identification includes metabolite feeding and molecular, biochemical and microscopic methods. CONCLUSION: The value of this cascade strategy is exemplified by new herbicides with MoAs in plastoquinone, auxin or very‐long‐chain fatty acid synthesis. Copyright © 2011 Society of Chemical Industry
Sprache
Englisch
Identifikatoren
ISSN: 1526-498X
eISSN: 1526-4998
DOI: 10.1002/ps.2300
Titel-ID: cdi_proquest_miscellaneous_926879342
Format
–
Schlagworte
Araceae - chemistry
,
Araceae - drug effects
,
Araceae - metabolism
,
Bioassays
,
Drug Discovery
,
Herbicides
,
Herbicides - chemistry
,
Herbicides - metabolism
,
Herbicides - pharmacology
,
Mass spectrometry
,
metabolic profiling
,
Metabolism
,
Metabolites
,
Metabolomics - methods
,
mode of action discovery
,
Molecular Structure
,
physiological profiling
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