Chemical and Pharmaceutical Bulletin, 2012/03/01, Vol.60(3), pp.306-314
2012
Details
- Autor(en) / Beteiligte
- Titel
- Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 2012/03/01, Vol.60(3), pp.306-314
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (−)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 μM, respectively.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.60.306Titel-ID: cdi_proquest_miscellaneous_926156017
- Format
- –
- Schlagworte
- Animals, Asteraceae, Cells, Cultured, Chrysanthemum - chemistry, Dendranthema zawadskii var. latilobum, eudesmane glucoside, Flavonoids - chemistry, Flavonoids - pharmacology, germacranolide, Inhibitory Concentration 50, Lipopolysaccharides - pharmacology, Macrophages - drug effects, Mice, Nitric Oxide - antagonists & inhibitors, nitric oxide inhibition, Plant Extracts - chemistry, Plant Extracts - pharmacology, Sesquiterpenes - chemistry, Sesquiterpenes - pharmacology, Sesquiterpenes, Eudesmane - chemistry, Sesquiterpenes, Eudesmane - pharmacology, Sesquiterpenes, Germacrane - chemistry, Sesquiterpenes, Germacrane - pharmacology, Spectrum Analysis - methods