Details

Autor(en) / Beteiligte

• Nomura, Sachiko
• Kami, Katsuya
• Kawano, Fuminori
• Oke, Yoshihiko
• Nakai, Naoya
• Ohira, Takashi
• Fujita, Ryo
• Terada, Masahiro
• Imaizumi, Kazuhiko
• Ohira, Yoshinobu

Titel

Effects of hindlimb unloading on neurogenesis in the hippocampus of newly weaned rats

Ist Teil von

• Neuroscience letters, 2012-02, Vol.509 (2), p.76-81

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• ► Effects of hindlimb unloading on hippocampal neurogenesis were studied in weaned rats. ► Proliferating cells and newly generated neurons were dramatically decreased following growth. ► Proliferating cell number was not influenced by hindlimb unloading. ► Newly generated neurons slightly decreased by hindlimb unloading. ► Hippocampal neurogenesis in weaned rats was not severely affected by hindlimb unloading. Effects of hindlimb suspension (HS) and ambulation recovery on hippocampal neurogenesis of newly weaned rats were studied by using immunohistochemical techniques. The number of proliferating cell nuclear antigen-positive (PCNA+) cells in the subgranular zone (SGZ) markedly decreased during normal growth. However, neither HS nor subsequent recovery caused additional changes in the number of PCNA+ cells. The number of doublecortin-positive (DCX+) neurons decreased gradually during normal growth. HS resulted in a further decrease in these neurons. However, DCX+ cell numbers became identical to the levels in age-matched controls after 14 days of recovery. PCNA and DCX-double positive cells in the SGZ were also observed, and their cell numbers were not affected by HS and 14-day ambulation. Thus, HS suppressed the generation of DCX+ neurons without affecting PCNA+ cells in the SGZ of weaned rats. Taken together, hippocampal neurogenesis in weaned rats was not severely affected by HS while it decreased significantly as they had grown.