Details

Autor(en) / Beteiligte

• Mizoguchi, Hirokazu
• Watanabe, Chizuko
• Sakurada, Tsukasa
• Sakurada, Shinobu

Titel

New vistas in opioid control of pain

Ist Teil von

• Current opinion in pharmacology, 2012-02, Vol.12 (1), p.87-91

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights ► Multiple μ-opioid receptors (splice variants) are involved in the antinociception induced by μ-opioid receptor agonists. ► Atypical μ-opioid receptors (specific splice variants) may be involved in the distinct antinociceptive profile of discrete agonists. ► Atypical μ-opioid receptors may be involved in the lack of rewarding effect of some μ-opioid receptor agonists. ► μ-Opioid receptor agonists specific for atypical μ-opioid receptors may be effective against morphine-resistant interactive pain. ► Atypical μ-opioid receptors may be the target molecule to produce analgesics better than morphine.