The international journal of biochemistry & cell biology, 2012-03, Vol.44 (3), p.447-451
2012
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- Autor(en) / Beteiligte
- Titel
- Cdc42: An important regulator of neuronal morphology
- Ist Teil von
- The international journal of biochemistry & cell biology, 2012-03, Vol.44 (3), p.447-451
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- ScienceDirect Pay Per View(PPV) Titles
- Beschreibungen/Notizen
- Regulation of neuronal morphology and activity-dependent synaptic modifications involves reorganization of the actin cytoskeleton. Dynamic changes of the actin cytoskeleton in many cell types are controlled by small GTPases of the Rho family, such as RhoA, Rac1 and Cdc42. As key regulators of both actin and microtubule cytoskeleton, Rho GTPases have also emerged as important regulators of dendrite and spine structural plasticity. Multiple studies suggest that Rac1 and Cdc42 are positive regulators promoting neurite outgrowth and growth cone protrusion, while the activation of RhoA induces stress fiber formation, leading to growth cone collapse and neurite retraction. This review focuses on recent advances in our understanding of the molecular mechanisms underlying physiological and pathological functions of Cdc42 in the nervous system. We also discuss application of different FRET-based biosensors as a powerful approach to examine the dynamics of Cdc42 activity in living cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1357-2725eISSN: 1878-5875DOI: 10.1016/j.biocel.2011.11.022Titel-ID: cdi_proquest_miscellaneous_922502139
- Format
- –
- Schlagworte
- actin, Actin Cytoskeleton - physiology, Animals, biosensors, Cdc42 (cell division cycle protein), cdc42 GTP-Binding Protein - genetics, cdc42 GTP-Binding Protein - metabolism, FRET-based biosensors, guanosinetriphosphatase, Humans, Memory, Long-Term - physiology, microfilaments, microtubules, Monomeric GTP-Binding Proteins - genetics, Monomeric GTP-Binding Proteins - metabolism, Nerve Growth Factors - genetics, Nerve Growth Factors - metabolism, nervous system, Neuronal morphology, Neurons - metabolism, Neurons - pathology, Sensory Receptor Cells - metabolism, Signal Transduction, Small GTPases of the Rho family