Details

Autor(en) / Beteiligte

• Gehring, U.
• de Jongste, J. C.
• Kerkhof, M.
• Oldewening, M.
• Postma, D.
• van Strien, R. T.
• Wijga, A. H.
• Willers, S. M.
• Wolse, A.
• Gerritsen, J.
• Smit, H. A.
• Brunekreef, B.

Titel

The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers

Ist Teil von

• Allergy (Copenhagen), 2012-02, Vol.67 (2), p.248-256

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• To cite this article: Gehring U, de Jongste JC, Kerkhof M, Oldewening M, Postma D, van Strien RT, Wijga AH, Willers SM, Wolse A, Gerritsen J, Smit HA, Brunekreef B. The 8‐year follow‐up of the PIAMA intervention study assessing the effect of mite‐impermeable mattress covers. Allergy 2012; 67: 248–256. Background:  Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite‐impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. Methods:  High‐risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen–impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper‐responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. Results:  At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. Conclusion:  Early intervention with mite‐impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.