Details

Autor(en) / Beteiligte

• O’Shea, T. Michael, MD, MPH
• Allred, Elizabeth N
• Kuban, Karl C.K., MD, Sm Epidem
• Dammann, Olaf, MD
• Paneth, Nigel, MD, MPH
• Fichorova, Raina, MD, PhD
• Hirtz, Deborah, MD
• Leviton, Alan, MD

Titel

Elevated Concentrations of Inflammation-Related Proteins in Postnatal Blood Predict Severe Developmental Delay at 2 Years of Age in Extremely Preterm Infants

Ist Teil von

• The Journal of pediatrics, 2012-03, Vol.160 (3), p.395-401.e4

Ort / Verlag

Maryland Heights, MO: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To evaluate the hypothesis that elevated levels of inflammation-related proteins in early postnatal blood predict impaired mental and motor development in extremely preterm infants. Study design We measured concentrations of 25 inflammation-related proteins in blood collected on postnatal days 1, 7, and 14 from 939 infants born before 28 weeks gestation. An elevated level was defined as a concentration in the highest quartile for gestational age and day of blood collection. We identified impaired development at age 24 months using the Bayley Scales of Infant Development, Second Edition . The primary outcomes were scores on the Mental Scale or the Motor Scale of <55 (more than 3 SDs below the mean). Results For 17 of the 25 inflammation-related proteins, 1 or more statistically significant associations ( P < .01) was found between an elevated blood level of the protein and a developmental impairment. Elevations on multiple days were more often associated with developmental impairment than were elevations present for only 1 day. The highest number of predictive elevations was found in day-14 blood. Conclusion In extremely preterm infants, elevated levels of inflammation-related proteins in blood collected on postnatal days 7 and 14, especially when sustained, are associated with impaired mental and motor development at age 2 years.